Cytokine Investigations in Organs and Tissues of Experimental Animals under Prenatal Hypoxic Conditions of Varying Severity

The paper presents the research results of varying severity experimental hypoxia influences on the content of cytokines (IGF-1, TNF-α, IL-1β, IL-4, IL-6, IFN-γ) in organs, tissues and cells (blood, liver, brain, uterus, adrenal glands, placenta, placental lymphocytes and macrophages) of pregnant rats. The results showed the increase of pro-inflammatory cytokines synthesis on the local and system levels during experimental hypoxia augmentation. There was found the difference between placental lymphocytes and macrophages secretion. These changes of cytokine profile leads to local deficiency of anti-inflammatory factors and indicate on development of pregnancy complications and “mother-placenta-fetus” system dysfunction. ZHANAR UTESHEVA, NATALYA KRAVTSOVA, LUDMILA DZOZ, TALGAT KUDAIBERGENOV, TATYANA KRAVTSOVA